1 Jan 2013 Experimentally, secondary mechanical hyperalgesia can be induced by cause central sensitization, but not high enough to cause overt pain.

8 Sep 2012 with primary and secondary hyperalgesia, respectively. Data suggest the presence of central sensitization among subjects with chronic SIS.

The number of studies investigating secondary hyperalgesia is growing; however basic knowledge of the physiologic aspects of (TKA) feel postoperative hyperalgesia in the second operated knee compared with the first knee. Ketamine is an important drug for central temporal summation and inhibition of secondary mechanical hyperalgesia. This study investigated whether central sensitization has a significant effect on hyperalgesia after consecutive operations. 2019-02-08 2021-03-19 Noxious stimulation of the skin with either chemical, electrical or heat stimuli leads to the development of primary hyperalgesia at the site of injury, and to secondary hyperalgesia in normal skin surrounding the injury. Secondary hyperalgesia is inducible in most individuals and is attributed to central neuronal sensitization.

Secondary hyperalgesia central sensitization

Central sensitization is largely considered a common, if not the most common, cause of chronic pain. In secondary hyperalgesia, the nerves in the general location of the pain become reactive in an increasingly wider area. Secondary hyperalgesia is inducible in most individuals and is attributed to central neuronal sensitization. Some individuals develop large areas of secondary hyperalgesia (high-sensitization responders), while others develop small areas (low-sensitization responders). HFS‐induced hyperalgesia is suitable to discriminate or compare individuals but it may not be sensitive to changes due to an intervention.

Secondary hyperalgesia is a type of central sensitization. Central sensitization is largely considered a common, if not the most common, cause of chronic pain. In secondary hyperalgesia, the nerves in the general location of the pain become reactive in an increasingly wider area.

that the development of secondary hyperalgesia to punc-tate mechanical stimuli following a standardised injury is caused by central changes in response to a conditioning stimulus and transmitted by A-delta fibers [1, 9–11]. The secondary hyperalgesia elicited by a clinical pain model may thus be a result of central sensitization.

Chronic bombardment of the spinal cord by C fibers has been implicated in the cause of central sensitization. Central sensitization is implicated in fibromy

Department of Anatomy, University College London,. Nature; 12/15/1983, av Å Ringqvist · 2019 — Clifford J. Woolf. Central sensitization: Implications for the diagnosis and treatment of pain. PAIN Volume 152, Issue 3, Supplement 2011 S2 - secondary hyperalgesia in the rat spinal dorsal horn is submodality selective Nociceptor modulated central sensitization causes mechanical hyperalgesia in Secondary hyperalgesia is due to central neuron sensitization and requires continuous nociceptor input from the zone of primary hyperalgesia for its maintenance. Secondary hyperalgesia implies only mechanical hyperalgesia, i.e. “allodynia“ and “pin prick“.

Se hela listan på academic.oup.com Secondary hyperalgesia refers to the sensitization that occurs because of changes in spinal cord processing. For example, through a process of central sensitization, the firing of dorsal horn nociceptors can change dramatically in the setting of injury (produced by either tissue or nerve damage). 2003-09-01 · The first model of secondary hyperalgesia suggests central sensitization to input from mechanosensitive, heat-insensitive nociceptors.
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Primary hyperalgesia cannot explain the clinical symptoms of pain summation, allodynia, or secondary hyperalgesia. It was speculated that these changes had to occur from alternations in the receptor fields within the central … 2021-03-19 Introduction Central sensitization plays a pivotal role in maintenance of pain and is believed to be intricately involved in several chronic pain conditions. One clinical manifestation of central sensitization is secondary hyperalgesia. The degree of secondary hyperalgesia presumably reflects individual levels of central sensitization. Chronic bombardment of the spinal cord by C fibers has been implicated in the cause of central sensitization.

(2) According to another definition, a hyperalgesia is primary when the reason is sensitization of nociceptors and secondary when it is due to alterations of central synaptic transmission.
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6 Jul 1999 Nociceptor sensitization and central sensitization are considered to underlie, respectively, development of primary hyperalgesia and secondary

9 Jun 2014 Additionally, areas of flare and secondary hyperalgesia were mapped, to heat) and central sensitization (punctate hyperalgesia and dynamic Secondary hyperalgesia, or central sensitization, involves spinal neuroplasticity and facilitation of supraspinal noxious transmission. The stimulus response Keywords: Central sensitization, definition, pain, nociception, secondary hyperalgesia. Go 30 Mar 2021 Central sensitisation predicts poor treatment outcomes in multiple patient populations. and in non-traumatic neck pain remote mechanical hyperalgesia is pain (pressure pain tolerance in the second toe adjusted OR 0 Secondary hyperalgesia (increased pinprick sensitivity surrounding the site of injury) is is commonly interpreted as resulting from central sensitization (CS). 15 Oct 2002 spinal circuits involved in triggering central sensitization and hyperalgesia.